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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA2 All Species: 15.45
Human Site: S1594 Identified Species: 28.33
UniProt: Q9BZC7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BZC7 NP_001597 2435 269873 S1594 N F V P P P P S P A P S D S P
Chimpanzee Pan troglodytes XP_001152577 2346 264166 C1517 K P G F G N R C L R E G W L P
Rhesus Macaque Macaca mulatta XP_001117819 2476 273629 S1621 N F V P P P P S P A P S D S P
Dog Lupus familis XP_537788 2395 264756 M1567 V G G R P P Q M R V V T G D I
Cat Felis silvestris
Mouse Mus musculus P41234 2434 270490 S1594 N F V P P P P S P A P S D S P
Rat Rattus norvegicus Q9ESR9 2434 270910 S1594 N F V P P P P S P A P S D S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 K1474 A C E C S N D K I K K M L P V
Chicken Gallus gallus XP_422330 2276 256293 S1484 P S P S C K C S T H K K L T M
Frog Xenopus laevis NP_001089022 2363 267334 M1542 N T S N E W T M P V V S P S V
Zebra Danio Brachydanio rerio NP_001139161 2268 254351 G1476 L C E C S C E G R K K M L P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 T912 L K P A G Y D T Q S S T K S A
Sea Urchin Strong. purpuratus XP_798273 1913 213253 E1121 T H S G R E I E S H S R T L I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 F1089 T L L S M S E F L M S S F D Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.1 96 82.2 N.A. 91 92.9 N.A. 39.1 35.7 36.5 37.7 N.A. N.A. N.A. 23.7 41.7
Protein Similarity: 100 52 96.6 86.1 N.A. 93.2 94.9 N.A. 55.7 53.5 54.7 54.5 N.A. N.A. N.A. 39 54.4
P-Site Identity: 100 6.6 100 13.3 N.A. 100 100 N.A. 0 6.6 26.6 0 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 6.6 100 20 N.A. 100 100 N.A. 0 13.3 26.6 0 N.A. N.A. N.A. 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. 26.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 0 0 0 0 0 31 0 0 0 0 8 % A
% Cys: 0 16 0 16 8 8 8 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 16 0 0 0 0 0 31 16 0 % D
% Glu: 0 0 16 0 8 8 16 8 0 0 8 0 0 0 8 % E
% Phe: 0 31 0 8 0 0 0 8 0 0 0 0 8 0 0 % F
% Gly: 0 8 16 8 16 0 0 8 0 0 0 8 8 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 16 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 16 % I
% Lys: 8 8 0 0 0 8 0 8 0 16 24 8 8 0 0 % K
% Leu: 16 8 8 0 0 0 0 0 16 0 0 0 24 16 0 % L
% Met: 0 0 0 0 8 0 0 16 0 8 0 16 0 0 8 % M
% Asn: 39 0 0 8 0 16 0 0 0 0 0 0 0 0 0 % N
% Pro: 8 8 16 31 39 39 31 0 39 0 31 0 8 16 39 % P
% Gln: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 8 % Q
% Arg: 0 0 0 8 8 0 8 0 16 8 0 8 0 0 0 % R
% Ser: 0 8 16 16 16 8 0 39 8 8 24 47 0 47 0 % S
% Thr: 16 8 0 0 0 0 8 8 8 0 0 16 8 8 0 % T
% Val: 8 0 31 0 0 0 0 0 0 16 16 0 0 0 16 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _